PeppiLibrary

Sexual Health

Gonadorelin peptide reference

Native GnRH decapeptide. Pulsatile dosing alternative to HCG for HPG axis support.

Last reviewed May 6, 2026 FDA-approved FDA approved
Peppi reviewing Gonadorelin notes
Default dose label100 mcg
Preferred routeSubQ
Frequency labelPulsatile (every 90–120 min for fertility) or 100 mcg subQ 1–2× daily as TRT adjunct
Storage window28 days mixed

Evidence snapshot

FDA-approved

Evidence maturityFDA approved
FDA-approved (historically) for diagnostic and fertility uses

Prescription medication

Route map

How records are usually labeled

1 SubQ
2 IV
3 IM
4 Intranasal

Rotate within abdomen for repeated dosing.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 14–28 days.
Use-by cue28 days after mixing
Mixed vial window28 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 5 mg vial
Dose 100 mcg
Route SubQ
Review 28d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Gonadorelin. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Gonadorelin is the synthetic form of native gonadotropin-releasing hormone (GnRH), a 10-amino-acid hypothalamic peptide that signals the pituitary to release LH and FSH. Unlike HCG (which acts directly on testes), gonadorelin works upstream and preserves the entire HPG axis. Approved historically for diagnostic GnRH stimulation testing and pulsatile fertility induction.

Also known as: GnRH, LHRH, Factrel, Lutrepulse.

TRT adjunct (alternative to HCG)Pulsatile fertility inductionGnRH stimulation testing

Mechanism and timing snapshot

Binds GnRH receptors on pituitary gonadotrophs, triggering pulsatile LH and FSH release. Continuous (non-pulsatile) administration paradoxically downregulates the HPG axis — exploited in agonist therapies like leuprolide.

Onset label5 min
Catalog onset field, when available.
Half-life label4 min
Plasma half-life ~2–4 minutes; effects on LH minutes
Duration label30 min
Catalog duration field, when available.
subQ Moderate
IV High
intranasal Low (~5%)

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose100 mcg
Catalog dose range25 mcg - 500 mcg
Default routeSubQ
Frequency labelPulsatile (every 90–120 min for fertility) or 100 mcg subQ 1–2× daily as TRT adjunct
Best time labelMorning consistency; pulsatile if mimicking natural rhythm.
Food noteNone.

Catalog protocol note

TRT adjunct: 100 mcg subQ daily or 2× daily. Fertility: pulsatile pump every 90 min.

Routes and site notes

Available route labelsSubQ, IV, IM, Intranasal
Preferred route labelSubQ
Common site labelsAbdomen
Site rotation noteRotate within abdomen for repeated dosing.

Chemistry

SequencepGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Amino acids10
Molecular formulaC55H75N17O13
Molecular weight1182.31 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size5 mg
DiluentBacteriostatic water
Diluent volume5 mL
Concentration note5 mg in 5 mL → 0.10 mL = 100 mcg (10 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 14–28 days.
Reconstituted shelf life28 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Generally well-tolerated
  • Mild flushing
  • Headache
  • Allergic reactions (rare)
  • Local reactions

Contraindications and warnings

  • Active hormone-sensitive cancer
  • Pregnancy
  • Continuous (non-pulsatile) dosing paradoxically suppresses the HPG axis.

Other considerations

  • TRT adjunct alternative to HCG — preserves upstream HPG signal.
  • Short half-life means pulsatile dosing matters; daily once-only dosing is suboptimal.
  • Less estrogen rise than HCG since LH spike is more physiological.

Evidence and regulatory context

Evidence levelFDA-approved (historically) for diagnostic and fertility uses
FDA approvedYes
Regulatory statusPrescription medication
Prescription requiredYes
Approved countriesUS, EU, and most others

Stacking and cycle notes

Stacks well withNot listed
Avoid combining noteGnRH antagonists, Continuous-dose GnRH agonists (paradoxical suppression)
Typical cycle labelongoing (TRT adjunct) or per protocol
Typical break labelPer clinician
Cycle guidanceTRT-adjunct use is typically continuous; fertility protocols are pulsatile and short-term.

Tracking tips

  • Pulsatile or twice-daily dosing — short half-life punishes once-daily protocols.
  • TRT alternative to HCG with less estrogen-spike potential.
  • Don't run continuous infusion expecting LH stimulation — paradoxical suppression.

References

Track it in Peppi

Keep Gonadorelin records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

Download on theApp Store Get it onGoogle Play

FAQ

What should I track for Gonadorelin?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Gonadorelin?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Gonadorelin records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026