PeppiLibrary

Growth Hormone

Hexarelin peptide reference

Most potent GHRP. Cardiac protective effects studied. Tachyphylaxis warning.

Last reviewed May 6, 2026 Human data Not FDA approved
Peppi reviewing Hexarelin notes
Default dose label100 mcg
Preferred routeSubQ
Frequency label1–3× daily
Storage window30 days mixed

Evidence snapshot

Human data

Evidence maturityHuman data
Phase 2 trials for cardiac applications; research-only for GH use

Research chemical (US)

Route map

How records are usually labeled

1 SubQ
2 IM

Rotate within abdomen.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 30 days.
Use-by cue30 days after mixing
Mixed vial window30 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 2 mg vial
Dose 100 mcg
Route SubQ
Review 30d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Hexarelin. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Hexarelin is a synthetic hexapeptide and the most potent of the classic GHRP family. Beyond GH release, it has documented direct cardioprotective effects independent of GH (binding the CD36 receptor on cardiac tissue). Tachyphylaxis (receptor desensitisation) develops within weeks of continuous use, requiring strict cycling.

Also known as: Examorelin.

Strong GH pulse stimulationCardiac researchShort-burst recovery cycles

Mechanism and timing snapshot

Ghrelin/GHS-R1a receptor agonist with additional CD36-mediated cardioprotective activity. Most potent GH-releasing capacity of the classic GHRPs.

Onset label15 min
Catalog onset field, when available.
Half-life label1 hr
Plasma half-life ~55 min
Duration label3 hr
Catalog duration field, when available.
subQ High
oral Low

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose100 mcg
Catalog dose range100 mcg - 200 mcg
Default routeSubQ
Frequency label1–3× daily
Best time labelPre-bed; pre-workout if dosing twice daily.
Food noteEmpty stomach for strongest pulse.

Catalog protocol note

100 mcg subQ 1–2× daily for 4–6 weeks max, then mandatory 4-week break.

Routes and site notes

Available route labelsSubQ, IM
Preferred route labelSubQ
Common site labelsAbdomen
Site rotation noteRotate within abdomen.

Chemistry

SequenceHis-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2
Amino acids6
Molecular formulaC47H58N12O6
Molecular weight887.05 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size2 mg
DiluentBacteriostatic water
Diluent volume2 mL
Concentration note2 mg in 2 mL → 0.10 mL = 100 mcg (10 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 30 days.
Reconstituted shelf life30 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Hunger spike
  • Mild flushing
  • Water retention
  • Cortisol elevation
  • Cardiac rhythm changes (rare)
  • Joint stiffness

Contraindications and warnings

  • Active malignancy
  • Cushing's syndrome
  • Pre-existing arrhythmias
  • Tachyphylaxis develops fast — mandatory cycling.
  • Not FDA-approved.

Other considerations

  • Strict cycling is non-negotiable: 4–6 weeks on, 4 weeks off.
  • Cardiac effects are documented — interesting research adjunct, not a daily-driver peptide.

Evidence and regulatory context

Evidence levelPhase 2 trials for cardiac applications; research-only for GH use
FDA approvedNo
Regulatory statusResearch chemical (US)
Prescription requiredNo
Approved countriesNot listed

Stacking and cycle notes

Stacks well withcjc-1295
Avoid combining noteOther ghrelin agonists simultaneously
Typical cycle label4–6
Typical break label4
Cycle guidanceMandatory breaks — tachyphylaxis is the main limitation.

Tracking tips

  • Don't run continuously — receptor desensitisation is the fastest of any GHRP.
  • Of the classic GHRPs, the strongest absolute GH spike per dose.
  • Worth respecting; not for the daily-stack-of-five-peptides crowd.

References

Track it in Peppi

Keep Hexarelin records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

Download on theApp Store Get it onGoogle Play

FAQ

What should I track for Hexarelin?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Hexarelin?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Hexarelin records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026